Understanding Irritable Bowel Syndrome

Abdominal Discomfort or Pain, Bloating, Constipation or Diarrhea

If you have some or all of these symptoms, you may suffer from a treatable medical condition called irritable bowel syndrome or IBS.  While not life threatening, this disorder can have significant impact on your life.

If you suffer from these symptoms, see your doctor, talk about your symptoms and ask about treatment that may be right for you.  For many sufferers, the abdominal discomfort, bloating and constipation of IBS can be managed effectively.  For those patients who seek care, physicians have treatment options that can relieve the abdominal pain, bloating and constipation of IBS and improve your quality of life, giving you the relief you deserve.

What Is Irritable Bowel Syndrome (IBS)?

IBS is a functional gastrointestinal (GI) disorder, a condition in which symptoms are due to dysfunction of the gut, not a structural problem like cancer. Nevertheless it is a real and treatable medical condition.  IBS is a chronic disorder that is characterized by recurring (symptoms that come and go over time) abdominal discomfort or pain associated with an altered bowel habit, either constipation, diarrhea or both.  IBS is different from routine, occasional constipation or diarrhea.

IBS is best defined by what it is NOT:

  • an anatomical or structural problem
  • an identifiable physical or chemical disorder
  • a cancer and will not cause cancer
  • a precursor of other gastrointestinal diseases
  • something you have to ‘just live with’

Contrary to popular belief, IBS is not a psychosomatic disorder. Stress and anxiety do not cause IBS. Instead, research suggests that IBS is dysfunction caused by changes in the nerves and muscles that control sensation and motility of the bowel.  IBS is 1.5—2 times more common in women than in men and is most commonly diagnosed in people under the age of 50.

Remember, IBS is a real medical condition, but it is not life threatening, and will not lead to other serious diseases.  Your GI tract may work differently, moving more slowly (or more quickly) than the average.

How Common is IBS?

IBS is prevalent.   In the United States, it is estimated that 10 to15 percent of the adult population suffers from IBS symptoms, yet only 5 to 7 percent of adults have been diagnosed with the disease.  IBS is the most common disease diagnosed by gastroenterologists and one of the most common disorders seen by primary care physicians.

How Does IBS Affect Patients’ Lives?

IBS can have a substantial impact on patients’ lives.  IBS symptoms can disrupt patients’ daily lives causing them to miss school or work, reduce social activities and interactions, skip meals or make other changes to diet and nutrition.  Consumer surveys have established that IBS is a major reason for increased absences and reduced productivity. So, there are compelling reasons for employers to be interested in improving access to treatment for patients with IBS.  Overall, patients who have untreated IBS report significant reductions in their overall quality-of-life. According to studies, people with IBS make more visits to their physicians, undergo more diagnostic tests, are prescribed more medications, miss more workdays, have lower work productivity, are hospitalized more frequently, and account for greater overall direct healthcare costs than patients without IBS.  Research reveals that IBS can have such a severe impact on quality of life that it has been linked to an increase in suicidal behavior.

Are There Different Types of IBS?

Generally, doctors classify IBS based on the cluster of symptoms experienced by the patient including IBS with constipation (abdominal discomfort or pain, bloating and constipation), IBS with diarrhea (abdominal discomfort or pain, urgency and diarrhea) or IBS with mixed symptoms (constipation and diarrhea).  There are approximately an equal number of patients in each of these classifications.  By determining the type of IBS that you suffer from, doctors are able to determine the right treatment.  So it’s important for you to describe all of your symptoms to your doctors including your bowel habit to your doctor.

What Causes Bowel Symptoms in Irritable Bowel Syndrome?

The exact cause of IBS is not clear.  However, recent medical research has shown that patients experiencing abdominal pain or discomfort, bloating and constipation or diarrhea may have a gastrointestinal (GI) tract that is more sensitive and works more slowly or quickly than it should.  Infrequent, occasional constipation or diarrhea is not abnormal.  Most people experience these symptoms from time to time. Diarrhea or constipation that is frequently accompanied by abdominal pain or bloating is a sign that you may have IBS and need to see the doctor.

When Should You See the Doctor?

If you experience recurring constipation or diarrhea that is associated with bothersome abdominal discomfort and/or bloating, you may have a real and treatable medical disorder called irritable bowel syndrome, and you should see your doctor or a gastrointestinal specialist to evaluate your symptoms.

What is a Gastroenterologist?

A gastroenterologist is a physician who specializes in disorders and conditions of the gastrointestinal tract.  Most gastroenterologists are board-certified in this subspecialty.  After completing the same training as all other physicians, they first complete at least another two years of additional training in order to attain board certification in internal medicine, then study for an additional 2-3 years to train specifically in conditions of the gastrointestinal tract.

How is IBS Diagnosed?

The doctor will start by asking you about your symptoms.  It’s important for the doctor to understand the symptoms you are experiencing.  So, describe all of your symptoms to your doctor.  Tell your doctor about your abdominal discomfort, bloating and your bowel symptoms. Your doctor may ask if you strain or have difficulty having a bowel movement and ask you to describe the appearance of your bowel movement.  Your doctor will rule out other disorders.  You doctor will ask if you have experienced rectal bleeding, significant weight loss, recurring fever, anemia, and chronic severe diarrhea.  These symptoms may need additional evaluation.

  • For most patients with IBS, a careful medical history, physical examination and a few blood tests are all that is necessary. Sometimes a colonoscopy (examination of the inside of the colon with a special tube with a TV camera on the end) is needed to exclude other conditions. Colonoscopic imaging should be performed in IBS patients with alarm features to rule out organic diseases and in those over the age of 50 years for the purpose of colorectal cancer screening.  The College recommends that African-Americans begin colorectal cancer screening at age 45.  When colonoscopy is performed in patients with IBS-D, obtaining random biopsies can be considered to rule out microscopic colitis

New Recommendations on Diagnostic Testing in IBS

Because of the low likelihood of uncovering organic diseases in patients with typical IBS symptoms, extensive diagnostic testing with thyroid function studies, stool for ova and parasites, and abdominal imaging should not be performed routinely in patients with typical IBS symptoms and no alarm features. Routine serologic screening for celiac sprue may be useful in patients with diarrhea-predominant IBS or the mixed type of IBS.  Lactose breath testing can be considered when lactose maldigestion remains a concern despite dietary modification.

Treatment by Adjusting Lifestyle, Diet & Stress

Traditionally much of the effort to treat IBS symptoms focused on lifestyle, diet and reduction of stress.  Although not proven scientifically, there are some dietary changes that some patients have found helpful and can be tried by individuals with little risk:

  • Avoid or limit the amount of gas-producing foods such as beans, onions, broccoli, cabbage, or any other foods that you have found to aggravate your IBS symptoms.
  • Try to slow down how fast you eat and avoid overeating.
  • Drinking excessive water will not improve bowel habits or IBS symptoms.
  • Drinking carbonated drinks (colas, pop, soda) can introduce gas into the intestines and cause abdominal pain. Chewing gum may lead to a significant amount of air being swallowed.
  • Avoid large quantities of the sugar substitute, sorbitol, which can cause excess gas, bloating, cramping and diarrhea.
  • Intolerance to milk sugar, lactose, is seen in up to 40% of patients with IBS.  Avoiding dairy products may be helpful in reducing symptoms of IBS in some patients.
  • The addition of wheat bran or other dietary fiber may be suggested by your doctor in an attempt to decrease your symptoms. Evidence of benefit is limited and fiber may aggravate bloating, especially if the amount in the diet is increased rapidly.
  • If you make a change to your diet, do it gradually to give your body time to adjust.

Psychological stress makes any condition harder to tolerate, and IBS and its symptoms are no exception.  Some patients have attained some relief through relaxation techniques and participation in regular exercise or a hobby.  IBS symptoms are not primarily manifestations of psychological disorders, but  behavioral therapies have been demonstrated to have positive impact on symptoms for some IBS patients.

What Other Treatments are Used for Symptoms of IBS?

Since there is no cure for IBS at present, medical treatments for IBS are used to reduce the patient’s predominant symptoms. There are a wide variety of available therapies, many of which improve patient well-being and individual IBS symptoms. Only a few therapies have been shown to be of benefit for all the symptoms of IBS. None of these treatments help every patient with IBS.

  • Trials suggest psyllium, fiber, certain antispasmodics, and peppermint oil are effective in IBS patients although the quality of the evidence is poor.
  • Patients often notice that certain foods exacerbate their IBS symptoms.  Avoiding those foods makes sense in those individuals. There is, however, insufficient evidence that food allergy testing or blanket exclusion diets are efficacious in IBS and their routine use outside a clinical trial is not recommended.
  • Anti-diarrheals reduce the frequency of stools in patients with IBS-D and laxatives increase stool frequency in IBS-C, but neither treatment affects pain.
  • Evidence suggests that some probiotics(“good bacteria”) may be effective in reducing overall IBS symptoms but more data are needed.
  • Some people with IBS are thought to have too many germs in the small intestine. Non-absorbable antibiotics reduce symptoms, sometimes for weeks after being given, particularly in diarrhea-predominant IBS.
  • Agents that work on the nerves in the gut have been tried to treat IBS. These medicines affect serotonin levels or serotonin receptors on the nerves and have proven value in some patients:
    • The 5HT 3 antagonist, alosetron, is efficacious in women with IBS with diarrhea.  Patients need to be carefully selected, however, because potentially serious side effects include severe constipation and reduced blood flow to the colon.  Current use of alosetron is regulated by a prescribing program set forth by the FDA. It can only be used in women with severe IBS with diarrhea who have failed other treatments.
    • The 5HT 4 agonist, tegaserod was modestly effective in IBS patients with constipation, but the possible risk of cardiovascular events such as stroke or heart attacks caused the FDA to  limited its use and resulted in its withdrawal from the market.  Currently, there are no 5-HT 4 receptor agonists available for use in North America, but new drugs in this category are being developed.
    • Tricyclic anti-depressants and more modern antidepressants (selective serotonin reuptake inhibitors) seem to be effective in IBS patients of all subtypes.  These drugs are used to reduce pain and other symptoms in IBS, not specifically to treat depression.
  • The lining of the gut has pores (“channels”) that let ions in and out of the lining cells of the gut. The selective C-2 chloride channel activator, lubiprostone, allows more chloride and water to enter the intestine and is efficacious in constipation-predominant IBS.
  • Psychological therapies, such as psychotherapy and hypnotism, also may provide benefit to IBS patients although the quality of evidence is poor.
  • Alternative therapies, such as unique Chinese herbal mixtures or acupuncture seem to show a benefit in IBS, but more work is needed before any recommendations about the use of these treatments can be made.
  • Some Key Points to Remember about IBS:

    In conclusion, here are some important things to remember about IBS:

    • Symptoms of abdominal discomfort, bloating, diarrhea and/or constipation may be part of a real medical condition called IBS
    • Through no fault of their own, patients have spent a significant amount of time suffering
    • Symptoms disrupt patients’ everyday lives, social interactions and work
    • Abdominal pain, bloating, diarrhea and/or constipation characterize a major portion of IBS sufferers
    • Many sufferers do not seek care for IBS
    • New therapies for IBS offer realistic hope to help restore quality of life which these patients deserve, but which many may have believed was out of reach